Key result
Patients with Fontan circulation had significantly reduced ejection fraction (43% vs 55%, P<0.05) and longitudinal strain (-13% vs -21%, P<0.05) compared to healthy individuals.
Why the study?
How do ventricular mechanics and geometry differ between adolescent and adult patients with a Fontan circulation and healthy individuals?
Cross-Sectional (n=200)
How do ventricular mechanics and geometry differ between adolescent and adult patients with a Fontan circulation and healthy individuals?
Absolute Event Rate: 43% vs 55%
p-value: p=<0.05
Functionally single ventricles after Fontan palliation exhibit significantly reduced systolic regional and global function, increased sphericity, and high intersegmental inhomogeneity compared to healthy controls.
No takes yet. Share an insight, caveat, or question.
Fontan patients warrant enhanced surveillance of ventricular function; leaves open prospective links to outcomes and interventions.
Rösner et al. (2018) conducted a cross-sectional in Single ventricle physiology and Fontan circulation (n=200). Fontan circulation vs. Healthy individuals was evaluated on Ejection fraction (EF) (p=<0.05). Patients with Fontan circulation had significantly reduced ejection fraction (43% vs 55%, P<0.05) and longitudinal strain (-13% vs -21%, P<0.05) compared to healthy individuals.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: