Key result
An acute change in systolic blood pressure can induce alterations in cardiac mechanics and local mechano-electrical coupling, potentially triggering lethal arrhythmias in the presence of a substrate.
Design
Review
Authors
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Acute BP changes may trigger arrhythmias in pro-arrhythmic substrates; leaves open whether targeting mechano-electrical coupling reduces sudden death risk.
This review highlights the role of acute mechanical loading and mechano-electrical coupling as a trigger for sudden cardiac death in patients with underlying pro-arrhythmic substrates.
George R. Sutherland (2017) conducted a review in Sudden cardiac death. Acute change in systolic blood pressure was evaluated. An acute change in systolic blood pressure can induce alterations in cardiac mechanics and local mechano-electrical coupling, potentially triggering lethal arrhythmias in the presence of a substrate.
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