Key result
Carriage of the T allele of the 584C/T polymorphism in the endothelial lipase gene was associated with a significantly reduced risk of coronary artery disease (OR 0.494), independent of HDL-C levels.
Why the study?
Does the 584C/T polymorphism of the EL gene associate with a reduced risk of premature CAD and altered HDL-C levels in males?
Case-Control (n=220)
No
Does the 584C/T polymorphism of the EL gene associate with a reduced risk of premature CAD and altered HDL-C levels in males?
Odds Ratio: 0.494 (95% CI 0.253–0.968)
Absolute Event Rate: 27.1% vs 32.5%
p-value: p=0.040
The 584C/T polymorphism (T allele) of the endothelial lipase gene is associated with a protective effect against premature coronary artery disease in Iranian men, independent of HDL-C levels.
Hypothesis-generating for EL variants in CAD risk; should not yet change practice or screening.
INTRODUCTION: Endothelial lipase (EL) is a protein from the triglyceride lipase family which plays an important role in high-density lipoprotein (HDL) metabolism. One of the most frequently studied variants is 584C/T which causes the amino acid threonine at codon 111 to convert to isoleucine. Many studies have shown the association of this variant with HDL-C level and CAD disease. METHODS: The population of this study consists of 140 patients (all males) with angiographically confirmed coronary artery disease (CAD) and 80 controls. Polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP) was carried out for genotyping of LIPG 584C/T. Data were analyzed using SPSS. RESULTS: The results of the study indicated that the frequency of T allele was significantly lower among CAD patients than among controls (0.27 vs 0.36, P = .004). However, no significant correlation was found between the 584C/T variant and serum HDL-C level. Multivariate regression analysis confirmed that the T allele is significantly associated with CAD disregarding the age, hypertension, hypercholesterolemia, diabetes and HDL-C (OR = 0.494, 95% CI = 0.253- 0.968, P =.040). CONCLUSION: It was concluded that the T allele was associated with protection from CAD in Fars province independent of HDL-C level.
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Toosi et al. (2015) conducted a case-control in Coronary Artery Disease (n=220). 584C/T polymorphism of EL gene (T allele) vs. CC genotype (C allele) was evaluated on Risk of Coronary Artery Disease (OR 0.494, 95% CI 0.253-0.968, p=0.040). Carriage of the T allele of the 584C/T polymorphism in the endothelial lipase gene was associated with a significantly reduced risk of coronary artery disease (OR 0.494), independent of HDL-C levels.
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