March 4, 1997Circulation

Septal Function During Left Ventricular Unloading

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Why the study?

Does abrupt LV unloading alter septal geometry and function in an open-chest dog model?

Population

Seven open-chest, anesthetized dogs

Comparison

Abrupt reduction of LV preload by clamping left… vs Baseline (before clamping)

Design

Preclinical

Authors

MMMarc R. MoonCardiac Surgery ABAnn F. BolgerCardiac Imaging ADAbe DeAndaThe University of Texas Medical Branch at Galveston

Discussion

Member takes

Implication

May contribute to RV impairment during LV support; hypothesis-generating in this animal model.

Structured PICO

Does abrupt LV unloading alter septal geometry and function in an open-chest dog model?

Population

Seven open-chest, anesthetized dogs

Intervention

Abrupt reduction of LV preload by clamping left atrial pressure between 0 and -2 mm Hg using a pressure-control servomechanism to withdraw blood from the left atrium

Comparator

Baseline (before clamping)

Outcome

Septal geometry and function (including LV pressure, LV end-diastolic cross-sectional area, septal shift, septal end-diastolic thickness, systolic septal thickening, and systolic septal output)surrogate

LV unloading alters interventricular septal geometry and reduces septal systolic thickening and output, which may contribute to impaired RV contractility during mechanical LV support.

Cite This Study

Moon et al. (1997) studied this question.

synapsesocial.com/papers/6a20e75469aa0ec678ecb455 https://doi.org/10.1161/01.cir.95.5.1320

Topics

Echocardiography

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Septal Function During Left Ventricular Unloading

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Septal Function During Left Ventricular Unloading

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider