Key result
Selective left ventricular volume loading via a shunt improved left and reduced right ventricular performance by changing the position of the interventricular septum in dogs.
Why the study?
Does selective left ventricular volume loading alter the position of the interventricular septum and affect ventricular performance in anesthetized open-chest dogs?
Population
Anesthetized open-chest dogs
Comparison
Selective left ventricular volume loading… vs Shunt closed (baseline state)
Design
Preclinical
Authors
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Supports acute septal interdependence in canines; leaves open human translation.
Does selective left ventricular volume loading alter the position of the interventricular septum and affect ventricular performance in anesthetized open-chest dogs?
In a canine model, selective left ventricular volume loading shifts the interventricular septum, which improves left ventricular performance but impairs right ventricular performance.
Molaug et al. (1983) studied Left ventricular volume loading. Selective left ventricular volume loading (shunt between subclavian artery and left atrium) vs. Shunt closed was evaluated on Cardiac performance and position of the interventricular septum. Selective left ventricular volume loading via a shunt improved left and reduced right ventricular performance by changing the position of the interventricular septum in dogs.
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