Why the study?
Does blockade of calcium or potassium channels affect electrophysiological parameters and vulnerability to ventricular fibrillation in a feline model of left ventricular hypertrophy?
Population
Feline aortic-banding model of left ventricular hypertrophy and concurrent control cats
Comparison
Verapamil and risotilide vs Sham-operated cats and baseline/no drug
Design
Preclinical
Authors
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Hypothesis-generating for potassium channel blockade in LVH; leaves open clinical translation to reduce ventricular vulnerability.
Does blockade of calcium or potassium channels affect electrophysiological parameters and vulnerability to ventricular fibrillation in a feline model of left ventricular hypertrophy?
In a feline model of LVH, blockade of the voltage-dependent potassium channel with risotilide, but not calcium channel blockade with verapamil, narrows the dispersion of refractoriness and protects against ventricular fibrillation.
Kowey et al. (1991) studied this question.
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