Why the study?
Does cardiopulmonary bypass with crystalloid prime reduce plasma albumin and calcium levels in patients undergoing cardiac surgery?
Does cardiopulmonary bypass with crystalloid prime reduce plasma albumin and calcium levels in patients undergoing cardiac surgery?
Cardiopulmonary bypass with crystalloid prime causes significant reductions in plasma albumin and calcium, which may adversely affect patients with poor left ventricular function or those taking digoxin or verapamil.
Post-bypass albumin and calcium reductions may warrant monitoring in vulnerable patients; leaves open whether repletion improves outcomes.
A significant fall in the levels of plasma albumin and a corresponding fall i in the levels of extracellular calcium occurred following cardiopulmonary bypass with the crystalloid prime. Postoperative hypoalbuminaemia was well tolerated, except in the patients with poor left ventricular function. Postoperative hypocalcaemia may increase digoxin sensitivity and may augment the negative inotropic effect of verapamil.
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Kaul et al. (1989) studied this question.
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