Key result
Current evidence suggests a bi-directional relationship between primary aldosteronism and obstructive sleep apnea via aldosterone-induced worsening of OSA and OSA-associated dysregulation of RAAS.
Why the study?
Both primary aldosteronism and obstructive sleep apnea contribute to hypertension and cardiovascular morbidity, but the relationship between them remains unclear with contradictory study results.
This review summarizes the bi-directional relationship between primary aldosteronism and obstructive sleep apnea, supporting current guidelines that recommend screening for primary aldosteronism in patients with obstructive sleep apnea and hypertension.
Both primary aldosteronism and obstructive sleep apnea are well-known causes of hypertension and contribute to increased cardiovascular morbidity and mortality independently. However, the relationship between these two entities remains unclear, with studies demonstrating contradictory results. This review aims to collate and put into perspective current available research regarding the association between primary aldosteronism and obstructive sleep apnea. The relationship between these two entities, clinical characteristics, clinical implications, outcomes of treatment, potential causal links and mechanisms are hereby presented.
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Loh et al. (2022) conducted a review in Primary aldosteronism and obstructive sleep apnea. Primary aldosteronism was evaluated. Current evidence suggests a bi-directional relationship between primary aldosteronism and obstructive sleep apnea via aldosterone-induced worsening of OSA and OSA-associated dysregulation of RAAS.
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