Key result
Angiotensin II interacts with the immune system in the brain via the AT1 receptor, inducing T-lymphocyte activation and inflammatory responses that facilitate the development of hypertension.
Why the study?
The review aimed to provide current concepts regarding angiotensin interaction with the immune system in the brain and the related implications for cardiovascular and neuroendocrine responses.
Design
Literature review
Authors
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Brain AT1 signaling in neuroinflammation merits targeted study; leaves open any clinical immunomodulatory role in hypertension.
This review highlights the significant role of brain angiotensinergic regulation of the immune system in the pathophysiology and development of hypertension.
Iovino et al. (2019) conducted a review in Hypertension. Angiotensin II was evaluated. Angiotensin II interacts with the immune system in the brain via the AT1 receptor, inducing T-lymphocyte activation and inflammatory responses that facilitate the development of hypertension.
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