Why the study?
Does oral losartan reduce body weight gain and fat mass in growing rats?
Population
Young lean or adult obese male Sprague-Dawley rats
Design
Preclinical
Follow-up
2 weeks
Authors
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Does not support clinical use; leaves open renin-angiotensin modulation of human adiposity.
Does oral losartan reduce body weight gain and fat mass in growing rats?
Losartan reduces body weight gain and fat mass in growing rats, highlighting the role of the peripheral renin-angiotensin system in adipose tissue development.
Crandall et al. (1994) studied this question.
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