Key result
A modified Chua circuit successfully simulated a V-trough in sympathetic nerve activity by increasing the resistive element between SNA and blood pressure, modeling impaired baroreflex.
A modified Chua circuit successfully simulates a V-trough in sympathetic nerve activity, providing a computational model for how depressed baroreflex may trigger sudden cardiac death.
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Models impaired baroreflex triggering sympathetic V-troughs and sudden death; hypothesis-generating for computational approaches and requires validation before clinical use.
Recently we have reported that a previously unidentified V-trough of sympathetic nerve activity (SNA) is a potential precursor of lethal cardiac events by examining 24-hour ambulatory electrocardiograms in which such an event was recorded by chance. The V-trough was marked by three consecutive compartments: a small variation lasting two hours, an abrupt descent lasting 30 min and a sharp ascent for 40 min. We reported that the hemodynamics consisting of heart rate, SNA and blood pressure (BP) is modeled excellently by the modification of a known chaotic electrical circuit, Chua circuit. A V-trough of SNA appears by increasing the resistive element between SNA and BP in the circuit, which corresponds to the impaired regulation of BP by SNA. This finding is consistent with an acknowledged finding that the depressed baroreflex (reflex of BP by SNA) may trigger a lethal arrhythmia.
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Motohisa Osaka (2011) studied Sudden cardiac death. Modified Chua circuit simulation was evaluated on Simulation of V-trough of sympathetic nerve activity. A modified Chua circuit successfully simulated a V-trough in sympathetic nerve activity by increasing the resistive element between SNA and blood pressure, modeling impaired baroreflex.
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