Key result
RhoA-dependent skeletal alpha-actin promoter activation requires beta1 integrin and a functional cytoskeleton in cardiomyocytes, with activation potentiated up to 15-fold by beta1 integrin co-expression.
Population
Neonatal cardiomyocytes and NIH 3T3 fibroblasts
Design
Preclinical
Authors
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No immediate clinical implications; leaves open whether beta1 integrin-RhoA crosstalk drives remodeling in vivo.
RhoA regulates SRF-dependent cardiac gene expression through cross-talk with the beta1 integrin signaling pathway via an organized actin cytoskeleton in cardiomyocytes.
Wei et al. (2001) studied this question. RhoA and beta1 integrin co-expression was evaluated on Skeletal alpha-actin promoter activation. RhoA-dependent skeletal alpha-actin promoter activation requires beta1 integrin and a functional cytoskeleton in cardiomyocytes, with activation potentiated up to 15-fold by beta1 integrin co-expression.
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