Key result
Hydropersulfides (RSSH) react with S-nitrosothiols (RS-NO) to liberate nitric oxide more proficiently than analogous thiols (RSH), providing a mechanism for NO-mediated vasorelaxation.
Why the study?
Although S-nitrosothiols are hypothesized to store and release nitric oxide to regulate vascular tone, few established mechanisms account for facile nitric oxide release from these species.
Comparison
Reaction of RS-NO with RSSH vs RSH
Design
In vitro chemical, computational, and biological vasorelaxation study
Authors
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May explain NO vasorelaxation in animal models; leaves open relevance to human cardiovascular signaling.
Demonstrates that hydropersulfides can react with S-nitrosothiols to release nitric oxide, providing a mechanistic explanation for NO-mediated vasorelaxation.
Zarenkiewicz et al. (2022) studied this question. Hydropersulfides (RSSH) vs. Thiols (RSH) was evaluated on Nitric oxide (NO) release and NO-mediated vasorelaxation. Hydropersulfides (RSSH) react with S-nitrosothiols (RS-NO) to liberate nitric oxide more proficiently than analogous thiols (RSH), providing a mechanism for NO-mediated vasorelaxation.
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