Key result
Nitrosopersulfide (SSNO-) releases NO, activates soluble guanylyl cyclase, induces vasodilation in aortic rings in vitro, and lowers blood pressure in rats in vivo.
Population
RFL-6 cells, aortic rings in vitro, and rats in vivo
Design
Preclinical
Authors
Loading...
Hypothesis-generating for SSNO- in vasodilation; leaves open any role in human hypertension pending clinical trials.
SSNO- is a stable S/N-hybrid molecule that mediates the chemical cross-talk between NO and sulfide, leading to sGC activation and vasodilation.
Cortese‐Krott et al. (2015) studied Vasodilation. Nitrosopersulfide (SSNO-) was evaluated on sGC activation and vasodilation. Nitrosopersulfide (SSNO-) releases NO, activates soluble guanylyl cyclase, induces vasodilation in aortic rings in vitro, and lowers blood pressure in rats in vivo.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: