Key result
Repeatedly high depression scores linked to ~104% greater risk of adverse HF outcomes.
Why the study?
Although anxiety and depression are linked to adverse outcomes in chronic HF, data on the temporal evolution of these symptoms are scarce.
Are repeatedly measured anxiety and depression symptoms associated with adverse clinical outcomes in patients with chronic heart failure?
Population
362 outpatients with chronic HF
Comparison
Repeatedly measured depression and anxiety symptoms via HADS questionnaire
Design
Prospective observational study
Follow-up
Maximum of 2.5 years
Authors
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Serial depression/anxiety scores may stratify risk in chronic HF; hypothesis-generating for screening trials.
Observational (n=362)
Are repeatedly measured anxiety and depression symptoms associated with adverse clinical outcomes in patients with chronic heart failure?
Hazard Ratio: 2.04 (95% CI 1.39–3.06)
p-value: p=< 0.001
Serial measurements of depression and anxiety symptoms identify chronic HF patients at increased risk of adverse clinical outcomes, suggesting the value of routine screening.
Kamar et al. (2024) conducted an observational in chronic heart failure (n=362). Depression and anxiety symptoms (HADS score) vs. Lower scores was evaluated on Composite of HF hospitalization, cardiovascular death, heart transplantation and left ventricular assist device (LVAD) implantation (HR 2.04, 95% CI 1.39-3.06, p=< 0.001). Repeatedly measured higher depression (HR 2.04; 95% CI 1.39-3.06; p<0.001) and anxiety (HR 1.57; 95% CI 1.07-2.30; p=0.022) scores were significantly associated with adverse clinical outcomes in HF.
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