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March 31, 2025Experimental and Clinical MedicineOpen Access

Predicting the risk of prolongation of the mean daily QTc interval in patients with arterial hypertension

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Why the study?

Hypertension is associated with dangerous arrhythmias diagnosable by QTc prolongation, prompting the need to determine predictors of mean daily QTc interval prolongation in hypertension.

Population

195 patients (166 with hypertension and 29 without hypertension)

Comparison

Normal vs prolonged average daily QTc interval

Key result

Male gender was significantly associated with an increased risk of mean daily QTc prolongation (OR 4.292) in patients evaluated for arterial hypertension.

Authors

NTN. E. Tselik

Discussion

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Overview

May support targeted QTc monitoring in hypertensive men; leaves open causality and requires prospective validation.

Study Design

Type

Cross-Sectional (n=195)

Multicenter

No

Structured PICO

P
Population
195 patients, including 166 with arterial hypertension and 29 without, evaluated to determine predictors of mean daily QTc interval prolongation.
O
Outcome
Prolongation of the mean daily QTc interval (>430 ms for men and >450 ms for women) measured by outpatient ECG monitoringsurrogate

Main Result

Odds Ratio: 4.292 (95% CI 1.337–13.779)

p-value: p=0.014

Male gender, BMI, blood pressure parameters, and time since hypertension diagnosis are significant predictors of QTc prolongation in patients with arterial hypertension.

Limitations

  • Single-center study
  • Relatively small sample size of patients with prolonged QTc (n=20)

Cite This Study

N. E. Tselik (2025) conducted a cross-sectional in Arterial Hypertension (n=195). Male gender vs. Female gender was evaluated on Prolongation of the mean daily QTc interval (OR 4.292, 95% CI 1.337-13.779, p=0.014). Male gender was significantly associated with an increased risk of mean daily QTc prolongation (OR 4.292) in patients evaluated for arterial hypertension.

synapsesocial.com/papers/6a20ed122e0c95b4d1ecb78fhttps://doi.org/10.35339/ekm.2025.94.1.tse
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