What question did this study set out to answer?

This research aims to assess the impact of statin therapy on endothelial function and circulating progenitor cells in vasospastic angina patients.

Effect of Additional Statin Therapy on Endothelial Function and Prognosis in Patients With Vasospastic Angina

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Randomized trial examines endothelial function improvement in vasospastic angina with statin therapy, indicating potential cardiovascular benefits.

This research aims to assess the impact of statin therapy on endothelial function and circulating progenitor cells in vasospastic angina patients.
133 patients underwent ergonovine provocation testing to assess endothelial function and were randomized to receive either rosuvastatin or placebo.
Endothelial function was measured via flow-mediated vasodilatation and circulating endothelial progenitor cells at baseline and after 6 months.
Vasospastic angina patients had significantly lower EPC counts (68.6 vs. 103.7/200 μL, p<0.001) and FMD (7.1% vs. 8.6%, p=0.044) compared to non-spasm patients.
After 6 months of rosuvastatin, EPC counts increased significantly (73.1 to 99.1/200 μL, p=0.002) and FMD improved (7.3% to 9.3%, p<0.001).

Yun et al. (2008) studied this question.

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Randomized trial examines endothelial function improvement in vasospastic angina with statin therapy, indicating potential cardiovascular benefits.