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February 1, 1978CirculationOpen Access

Reduction of coronary blood flow during coronary artery spasm occurring spontaneously and after provocation by ergonovine maleate.

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Why the study?

Does coronary artery spasm occurring spontaneously or after provocation by ergonovine maleate alter coronary blood flow and myocardial oxygen extraction?

Population

1 50-year-old man suffering from recurrent chest pain accompanied by transient ST-segment elevation

Comparison

Ergonovine maleate provocation vs Baseline / spontaneous chest pain

Design

Case_report

Authors

DRDonald R. RicciInterventional CardiologyAOArthur E. OrlickStanford UniversityPDPaul W. DohertyUnited States Department of Veterans Affairs

Discussion

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Implication

Highlights spasm-induced flow reduction and oxygen extraction in variant angina; leaves open broader applicability.

Structured PICO

Does coronary artery spasm occurring spontaneously or after provocation by ergonovine maleate alter coronary blood flow and myocardial oxygen extraction?

P
Population
1 50-year-old man suffering from recurrent chest pain accompanied by transient ST-segment elevation
I
Intervention
Ergonovine maleate provocation
C
Comparator
Baseline / spontaneous chest pain
O
Outcome
Coronary sinus blood flow and arteriovenous oxygen differencesurrogate

Coronary artery spasm produces a marked deficit in coronary blood flow associated with increased myocardial oxygen extraction, followed by a hyperemic response upon release.

Cite This Study

Ricci et al. (1978) studied this question.

synapsesocial.com/papers/6a20eed43b29bd64a5eb1937https://doi.org/10.1161/01.cir.57.2.392
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1ELECTROCARDIOGRAPHIC STUDIES DURING ATTACKS OF ANGINA PECTORIS AND OF OTHER PAROXYSMAL PAIN1931 · 31 citations
  2. 2Origin of great cardiac vein and coronary sinus drainage within the left ventricle1976 · 85 citations
  3. 3Spontaneously and Pharmacologically Provoked Coronary Arterial Spasm in Prinzmetal Variant Angina1976 · 46 citations
  4. 4Coronary Arterial Spasm in Prinzmetal Angina1973 · 592 citations
  5. 5Variant Angina Pectoris1970 · 152 citations