Key result
High-density mapping using extended early-meets-late software demonstrated that focal atrial tachycardias arise from low-voltage areas (mean 3.2 cm2) protected by zones of conduction delay in all patients.
Why the study?
The pathophysiological mechanism of focal atrial tachycardias remains obscure.
Does high-density mapping using EEML software characterize the electrophysiological substrate in patients with focal atrial tachycardias?
Observational (n=15)
No
Does high-density mapping using EEML software characterize the electrophysiological substrate in patients with focal atrial tachycardias?
High-density mapping with EEML software demonstrates that focal atrial tachycardias originate from low-voltage areas protected by zones of slow conduction.
Background The pathophysiological mechanism of focal atrial tachycardias (AT) remains obscure. Methods Fifteen patients (6 males, age 45 ± 18) with focal AT underwent high‐density activation mapping using a new software called extended early‐meets‐late (EEML). Results Irrespective of the arrhythmia mechanism, low bipolar voltage fractionated signals (0.14 ± 0.10 mV) were seen at the earliest activation site. The mean low‐voltage area (LVA) at the earliest activation site was 3.2 ± 1.0 cm 2 . EEML mapping revealed zones of conduction delay at the borders of LVAs. Conclusions LVAs protected by zones of slow conduction appears to play an important role in the initiation and maintenance of focal ATs.
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Letsas et al. (2020) conducted an observational in Focal atrial tachycardia (n=15). High-density mapping using extended early-meets-late (EEML) software was evaluated on Identification of low-voltage areas and zones of conduction delay at the earliest activation site. High-density mapping using extended early-meets-late software demonstrated that focal atrial tachycardias arise from low-voltage areas (mean 3.2 cm2) protected by zones of conduction delay in all patients.
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