Key result
Manganese-calcium contrast agents increased left ventricular developed pressure by up to 56% and reduced tissue manganese uptake compared to manganese alone, potentially reducing MR efficacy.
Why the study?
Does adding high calcium to manganese-releasing contrast agents affect cardiac function and magnetic resonance efficacy in perfused guinea pig hearts?
Does adding high calcium to manganese-releasing contrast agents affect cardiac function and magnetic resonance efficacy in perfused guinea pig hearts?
Adding high calcium to manganese-releasing contrast agents may be counterproductive by inducing strong positive inotropy and reducing magnetic resonance efficacy.
Calcium addition to manganese contrast may induce inotropy while reducing MR efficacy in isolated hearts; hypothesis-generating and leaves clinical translation open.
OBJECTIVES: Manganese ions (Mn) enter cardiomyocytes via calcium (Ca) channels and enhance relaxation intracellularly. To prevent negative inotropy, new Mn-releasing contrast agents have been supplemented with high Ca. The study aim was to investigate how this affects cardiac function and magnetic resonance efficacy. MATERIALS AND METHODS: MnCl2 based contrast agents, manganese and manganese-calcium (Ca:Mn 10:1), were infused during 4 repeated washin-washout sequences in perfused guinea pig hearts. [Mn] were 10, 50, 100 and 500 microM. RESULTS: During washin, manganese depressed left ventricular developed pressure (LVDP) by 4, 9, 17, and 53% whereas manganese-calcium increased LVDP by 13, 18, 25, and 56%. After experiments, tissue Mn contents (nmol/g dry wt) were control <40, manganese 3720, and manganese-calcium 1620. T1 was reduced by 85-92% in Mn-enriched hearts. CONCLUSIONS: High Ca supplements to Mn-releasing contrast agents may be counterproductive by inducing a strong positive inotropic response and by reducing the magnetic resonance efficacy.
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Bruvold et al. (2005) studied this question. Manganese-calcium contrast agent (Ca:Mn 10:1) vs. Manganese contrast agent was evaluated on Left ventricular developed pressure (LVDP). Manganese-calcium contrast agents increased left ventricular developed pressure by up to 56% and reduced tissue manganese uptake compared to manganese alone, potentially reducing MR efficacy.
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