Why the study?
Does hyperthyroidism augment the effects of norepinephrine on myocardial adenyl cyclase activity and contractile state in cat hearts?
Does hyperthyroidism augment the effects of norepinephrine on myocardial adenyl cyclase activity and contractile state in cat hearts?
Hyperthyroidism does not alter the sensitivity of myocardial adenyl cyclase or papillary muscle contractility to norepinephrine, suggesting the hyperdynamic circulatory state of hyperthyroidism is not due to increased cardiac sensitivity to catecholamines.
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Challenges assumption of catecholamine hypersensitivity in hyperthyroidism; leaves open alternative mechanisms for its hyperdynamic state.
Levey et al. (1969) studied this question.
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