Key result
In rabbit ventricular myocytes, lower-efficiency NCX-mediated CICR predominates in early development (37% in 3-day-olds) and decreases as L-type Ca2+ channel-mediated CICR increases with age.
Population
Rabbit ventricular myocytes at 3, 10, 20, and 56 days of age
Design
Preclinical
Authors
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Animal data on maturing Ca2+ release mechanisms in rabbits leave open translation to human neonates; no clinical implications yet.
In rabbit ventricular myocytes, lower-efficiency NCX-mediated CICR predominates in early developmental stages and is gradually replaced by more efficient L-type Ca2+ channel-mediated CICR with age.
Huang et al. (2007) studied Developmental changes in rabbit ventricular myocytes. Ontogeny (age) vs. Different age groups (e.g., 3-day-old vs 56-day-old) was evaluated on Ca2+-induced Ca2+ release (CICR) mechanisms (NCX-mediated vs ICa-mediated). In rabbit ventricular myocytes, lower-efficiency NCX-mediated CICR predominates in early development (37% in 3-day-olds) and decreases as L-type Ca2+ channel-mediated CICR increases with age.
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