Key result
In dogs, the atrial depolarization wave originates from a multicentric pacemaker complex distributed over a 30- to 40-mm area, with specific sites dominating excitation at different heart rates.
Population
Dogs (canine model)
Design
Preclinical
Authors
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Challenges unifocal sinus node model in dogs; hypothesis-generating for human mapping and requires clinical validation.
Demonstrates that the atrial pacemaker complex in dogs is widely distributed and functionally differentiated by heart rate, challenging the concept of a unifocal sinus node origin.
Boineau et al. (1980) studied Rate-related changes in the electrocardiographic P wave. Observation of atrial depolarization wave origin was evaluated on Origin of the atrial depolarization wave. In dogs, the atrial depolarization wave originates from a multicentric pacemaker complex distributed over a 30- to 40-mm area, with specific sites dominating excitation at different heart rates.
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