What question did this study set out to answer?

This research aims to identify and characterize the estrogen-responsive element in the uteroglobin promoter region.

The Uteroglobin Promoter Contains a Noncanonical Estrogen Responsive Element

View Full Paper

Ask AI

Bookmark

This research aims to identify and characterize the estrogen-responsive element in the uteroglobin promoter region.
Identified the functional estrogen-responsive element located between -265 and -252 in the uteroglobin promoter.
Conducted gene transfer experiments with hybrid constructions linked to chloramphenicol acetyltransferase gene.
Performed binding experiments with estrogen receptor to analyze interactions with the ERE.
Estrogen-responsive element was functional as deletion reduced responsiveness.
Synthetic oligonucleotide conferred estrogen inducibility to unresponsive promoter.
The affinity of the uteroglobin ERE is lower compared to the vitellogenin A2 ERE from Xenopus.

No takes yet. Share an insight, caveat, or question.

Randomized trial shows estrogen responsiveness in uteroglobin gene expression, suggesting hormonal control mechanisms.

Slater et al. (1990) studied this question.

View Full Paper

Ask AI

Bookmark