Key result
Variant angina was associated with significantly decreased flow-mediated dilation (9.2% vs. 12.4%) and increased inflammatory markers including von Willebrand factor compared to controls.
Why the study?
Are increased inflammatory markers and endothelial dysfunction associated with variant angina?
Case-Control (n=60)
No
Are increased inflammatory markers and endothelial dysfunction associated with variant angina?
Absolute Event Rate: 9.2% vs 12.4%
p-value: p=0.021
Variant angina is associated with increased inflammatory markers and endothelial dysfunction, suggesting a role for inflammation in its pathogenesis.
May implicate inflammation in variant angina; hypothesis-generating and requires prospective validation before clinical consideration.
Background and ObjectivesEndothelial dysfunction and increased vascular inflammation may be associated with variant angina (VA).However, their exact roles remain to be clarified.The aim of the presents study is to investigate whether the level of inflammation markers and the flow-mediated dilation (FMD) are related to VA. Subjects and MethodsThe study included 46 patients (VA group: 53.912.0years, 20 males) with positive spasm provocation tests and they were without significant coronary stenosis, and 14 patients (control group: 46.613.5 years, 7 males) with negative spasm provocation tests and they were without significant coronary stenosis.The clinical characteristics and inflammatory markers, including the high sensitive C-reactive protein (hsCRP) level, the monocyte count and the von Willebrand factor (vWF) level, and the FMD were compared between the two groups.The FMD and inflammatory markers were measured in the morning before performing the ergonovine provocation coronary angiogram.ResultsThe level of vWF was significantly higher in the VA group than in the control group (166.541.9% vs. 118.065.3%,respectively, p=0.029).The FMD was significantly decreased in the VA group compared with the control group (9.24.3% vs. 12.44.2%,respectively, p=0.021).Nitratemediated dilation did not differ between the two groups.The levels of the monocyte count, hs-CRP and homocysteine were higher in the VA group than in the control group (554.7261.0/mm 3 vs.440.7136.0/mm 3 , respectively, p=0.039; 0.30.4mg/dL vs. 0.10.1 mg/dL, respectively, p=0.029; 7.544.0mol/Lvs. 5.92 1.6mol/L, respectively, p=0.033).ConclusionThe results of this study suggested that increased inflammatory markers and endothelial dysfunction may be associated with variant angina.(
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Cho et al. (2007) conducted a case-control in Variant Angina (n=60). Variant angina (positive spasm provocation test) vs. Negative spasm provocation test (controls) was evaluated on Flow-mediated dilation (FMD) (p=0.021). Variant angina was associated with significantly decreased flow-mediated dilation (9.2% vs. 12.4%) and increased inflammatory markers including von Willebrand factor compared to controls.
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