Population
Isolated mouse phrenic-hemidiaphragm preparations
Comparison
Muscarine, atropine, fasciculin-2, pertussis… vs Untreated baseline or normal vs AChE-deficient…
Design
Preclinical
Authors
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Highlights receptor-specific ACh modulation by AChE status; leaves open M1/M2 targeting in neuromuscular transmission disorders.
M1 and M2 muscarinic receptors have opposite presynaptic functions in modulating quantal acetylcholine release at the neuromuscular junction, depending on acetylcholinesterase activity.
Minic et al. (2002) studied this question.
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