The study provides the first single-cell PCR evidence that m1 muscarinic receptors are expressed on adult rat ventricular myocytes and mediate stimulatory Ca2+ transient responses to high-dose cholinergic agonists.
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Indicates m1 receptors stimulate Ca2+ in rat myocytes; leaves open human relevance and therapeutic translation.
Sharma et al. (1996) studied this question.
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