February 1, 1997Life SciencesOpen Access

Does mammalian heart contain only the m2 muscarinic receptor subtype?

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Population

Adult rat ventricular myocytes

Design

Preclinical

Authors

VSVirendra K. SharmaUniversity of Miami HCHenry M. ColecraftElectrophysiology LRLisa E. RubinLife University

Discussion

Member takes

Implication

Functional m1 mAChRs modulate Ca transients in rat myocytes; leaves open human relevance or therapeutic targeting.

Structured PICO

Population

Adult rat ventricular myocytes

Intervention

Administration of m1 mAChR antagonist pirenzepine and muscarinic agonist carbachol

Outcome

Expression of mAChR subtypes (mRNA and protein) and effect on Ca transientssurrogate

Adult rat ventricular myocytes express both m1 and m2 muscarinic receptors, and m1 receptors are functionally involved in the stimulatory effects of muscarinic agonists.

Cite This Study

Sharma et al. (1997) studied this question.

synapsesocial.com/papers/6a98f0e04f4bbec9e275bb91 https://doi.org/10.1016/s0024-3205(97)00043-x

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