Key result
In adult rat cardiomyocytes, carbachol increased IP-formation, which was inhibited by the M3-receptor antagonist darifenacin, indicating the presence of functional M3-receptors.
Demonstrates the presence of functional M3-muscarinic receptors coupled to the phospholipase C/IP3 pathway in adult rat ventricular cardiomyocytes.
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Remains preclinical and hypothesis-generating; leaves open functional M3-receptor roles in human cardiomyocytes.
Pönicke et al. (2003) studied this question. Carbachol vs. Basal / M-receptor antagonists was evaluated on [(3)H]-inositol phosphate (IP) formation. In adult rat cardiomyocytes, carbachol increased IP-formation, which was inhibited by the M3-receptor antagonist darifenacin, indicating the presence of functional M3-receptors.
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