Status, despair, and epigenetic age acceleration: Chains of risk?

Biological age acceleration predicts multiple "diseases of aging." Objective and subjective social statuses have both been prospectively linked to this outcome. An established chain-of-risk framework suggests that "effects" of each may be mediated by one's subsequent structural position. A separate deaths-of-despair literature identifies a person's sense of futility as another potential link. Such chains remain underexplored. The current study used data from three waves (2008-2016) of the Health and Retirement Study (HRS) to fill these gaps. The analysis was done through a counterfactual regression-with-residuals (RWR) approach. Asimulated decline in a person's objective but not subjective status predicted their age acceleration 8 years later. Contrary to chain-of-risk conceptions, intermediate social standing did not channel effects. Neither did despair. Findings were more consistent with a direct "material shocks" explanation for status-aging linkages than an indirect or psychosocial one. Implications for aging theory and for interventions are discussed.