Key result
Metabolic syndrome in obese adolescents was associated with significantly increased left ventricular mass in males (258.7 vs 205.9 g) and visceral fat thickness in females.
Why the study?
Studies show different associations between metabolic syndrome and cardiovascular disease in adolescents, prompting the identification of probable cardiovascular risk factors in obese adolescents with metabolic syndrome.
Cross-Sectional (n=65)
No
Absolute Event Rate: 258.7% vs 205.9%
p-value: p=0.008
In obese adolescents, the presence of metabolic syndrome is associated with increased visceral fat thickness and left ventricular mass index, suggesting these are early markers for future cardiovascular risk.
Objective: There are studies that show different associations between metabolic syndrome (MS) and cardiovascular disease in adolescent. This study is aimed to identify probable cardio-vascular risk factors in obese adolescents with MS. Methods: Sixty-five obese adolescents with a body mass index (BMI) > 95 percentile were enrolled and divided into two groups with MS or without MS. Left ventricular mass (LVM), left ventricular mass index, ejection fraction, epicardial fat thickness, visceral fat thickness (VFT) and carotid intima-media thickness were measured. Anthropometric and blood chemistry parameters were estimated. Above parameters were compared based on presence or absence of MS. Results: The prevalence of MS was 23.1% in obese adolescents. LVM showed significant correlation with body mass index (BMI), hip circumference (HC), fat mass, total cholesterol (TC), LDL-cholesterol (LDL-C) and waist circumference (WC). VFT significantly correlated with WC, BMI, hip circumflex (HC), obesity index (OI), fat %, fat mass, insulin, TC, LDL-C, insulin, triglyceride (TG), glucose, homeostatic model assessment for insulin resistance (HOMA-IR) and leptin. Conclusions: Screening for the MS in overweight adolescents may help to predict risk of future cardiovascular disease. These data suggest that LVMI and VFT are significant parameters for predicting cardiovascular disease risk in obese adolescents.
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Lee et al. (2021) conducted a cross-sectional in Obesity with Metabolic Syndrome (n=65). Metabolic syndrome vs. Obese adolescents without metabolic syndrome was evaluated on Left ventricular mass (LVM) in males (p=0.008). Metabolic syndrome in obese adolescents was associated with significantly increased left ventricular mass in males (258.7 vs 205.9 g) and visceral fat thickness in females.
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