Key result
Elevated baseline non-HDL cholesterol was associated with short-term complications following acute myocardial infarction (mean 189 ± 8 vs 124 ± 10 mg/dl; p=0.08373).
Why the study?
Does baseline cholesterol level affect the short term prognosis of acute myocardial infarction?
Observational (n=100)
No
Does baseline cholesterol level affect the short term prognosis of acute myocardial infarction?
p-value: p=0.08373
Higher baseline total and non-HDL cholesterol levels are associated with a worse short-term prognosis and higher complication rates in patients with acute myocardial infarction.
May warrant closer post-MI monitoring in hypercholesterolemic patients; leaves open whether targeting non-HDL improves short-term outcomes.
Acute myocardial infarction is a major cause of morbidity and mortality, more so in Indians. To establish the hypothesis that cholesterol level affects the short term prognosis of acute myocardial infarction. One hundred patients with acute myocardial infarction attending a rural tertiary care hospital were selected randomly and assessed for complications their lipid profiles were measured and mean values calculated and compared for complicated and uncomplicated groups. In the group without complications 79.1% had total cholesterol <250 mg/dl and 85.58% had non-HDL cholesterol <160 mg/dl. In the group with complications 69.7% had total cholesterol >250 mg/dl and 75.76% had non-HDL cholesterol >160 mg/dl. The mean non-HDLC values for the two groups were 124 ± 10 and 189 ± 8 respectively (p = 0.08373). The study shows strong relation between the short term prognosis of acute myocardial infarction and baseline cholesterol values, especially non-HDL cholesterol.
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Binu et al. (2012) conducted an observational in Acute myocardial infarction (n=100). Elevated baseline cholesterol (total and non-HDL) vs. Lower baseline cholesterol was evaluated on Short term complications (p=0.08373). Elevated baseline non-HDL cholesterol was associated with short-term complications following acute myocardial infarction (mean 189 ± 8 vs 124 ± 10 mg/dl; p=0.08373).
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