Key result
Retroperitoneal and visceral adipose tissue thicknesses did not significantly differ between patients with colorectal cancer and healthy controls, although subcutaneous adipose tissue was higher in controls.
Why the study?
The study was conducted to examine the relationship between obesity and the subcutaneous, visceral, and retroperitoneal adipose tissue thicknesses of the abdomen.
Does abdominal adipose tissue distribution differ between patients with colorectal cancer and healthy controls?
Case-Control (n=130)
No
Does abdominal adipose tissue distribution differ between patients with colorectal cancer and healthy controls?
Absolute Event Rate: 15.71% vs 13.5%
p-value: p=0.246
Abdominal adipose tissue thicknesses (visceral and retroperitoneal) measured by CT did not significantly differ between patients with diagnosed colorectal cancer and healthy controls, though subcutaneous fat was higher in controls.
Visceral adipose thickness was not associated with colorectal cancer; leaves open its role and requires prospective confirmation.
Aim: To examine the relationship between obesity and the subcutaneous, visceral and retroperitoneal adipose tissue thicknesses of the abdomen. Materials and Methods: The study included 62 control and 68 colorectal cancer patients. Abdominal computed tomography of the patients, which were taken within the last 6 months before preoperative or colonoscopic examination were evaluated. Colorectal cancer patients were divided into two groups as proximal and distal according to tumor localization. Subcutaneous, visceral and retroperitoneal adipose tissue thicknesses of the abdomen were measured using abdominal computed tomography scans. Results: There was no statistically significant difference between the colorectal cancer group and the control group in terms of body mass index, retroperitoneal and visceral adipose tissue thickness and gender (p=0.091; 0.246; 0.531; 0.190,respectively). The mean age of the colorectal cancer group was higher (p<0.001). The mean subcutaneous adipose tissue thickness of the control group was higher (p=0.045). There was no statistically significant difference between the proximal and distal colorectal cancer group in terms of age, retroperitoneal, subcutaneous and visceral adipose tissue thickness (p=0.734; 0.916; 0.800; 0.170, respectively). The mean body mass index of the group with distal mass was higher (p=0.028). The proportion of males was higher in the group with distal mass than in the group with proximal mass (p=0.024). Conclusion: In the risky population evaluating the adipose tissue in the abdomen and its distribution before the colorectal cancer is diagnosed or the symptoms develop will indicate which patients should be followed up in more detail and help to prevent more cases of colorectal cancer.
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Ülger et al. (2021) conducted a case-control in Colorectal cancer (n=130). Abdominal adipose tissue distribution vs. Healthy controls was evaluated on Retroperitoneal adipose tissue thickness (mm) (p=0.246). Retroperitoneal and visceral adipose tissue thicknesses did not significantly differ between patients with colorectal cancer and healthy controls, although subcutaneous adipose tissue was higher in controls.
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