What question did this study set out to answer?

To evaluate the diagnostic utility of serum leptin and resistin levels alongside quantitative abdominal fat distribution parameters for colorectal neoplasms.

June 17, 2020International Journal of Cancer and Biomedical ResearchOpen Access

Adipocytokine, leptin, and resistin in combination with quantitative visceral adiposity as predictors of colorectal neoplasm: A case-control study

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To evaluate the diagnostic utility of serum leptin and resistin levels alongside quantitative abdominal fat distribution parameters for colorectal neoplasms.
Conducted a case-control study with N=80 participants classified via endoscopy and histopathology into colon cancer (n=30), colonic adenoma (n=25), and control (n=25) cohorts.
Quantified serum leptin and resistin concentrations and calculated abdominal fat distribution metrics via computed tomography (CT) scans.
Applied multivariable logistic regression to identify independent predictors of colorectal cancer development.
Serum leptin and resistin were identified as significant independent predictors of colorectal cancer development in multivariable logistic regression.
The visceral-to-superficial fat ratio emerged as the most significant predictor among all quantitative CT-based fat parameters.
Psoas muscle volume and visceral fat volume differed significantly across the cancer, adenoma, and control groups.

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Implication

Case-control study demonstrates leptin, resistin, and visceral fat ratios predict colorectal neoplasms in patients, highlighting biomarkers for earlier diagnosis.

Cite This Study

Shafik et al. (2020) studied this question.

synapsesocial.com/papers/6a71b61784cc45bb7bdfff1d https://doi.org/10.21608/jcbr.2020.28094.1029

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Implication

Case-control study demonstrates leptin, resistin, and visceral fat ratios predict colorectal neoplasms in patients, highlighting biomarkers for earlier diagnosis.

Adipocytokine, leptin, and resistin in combination with quantitative visceral adiposity as predictors of colorectal neoplasm: A case-control study

Key Points

Discussion

Implication

Cite This Study

Adipocytokine, leptin, and resistin in combination with quantitative visceral adiposity as predictors of colorectal neoplasm: A case-control study

Key Points

Discussion

Implication

Cite This Study

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