Predictors of Hemorrhage Following Intra-Arterial Thrombolysis for Acute Ischemic Stroke: The Role of Pial Collateral Formation

104 consecutive patients with acute ischemic stroke who underwent intra-arterial thrombolysis, mean age 68.0 years, 56 men. Key inclusion: treated within 6 hours of symptoms (or up to 12 hours for basilar artery occlusion with specific criteria).

Intra-arterial thrombolysis using tissue plasminogen activator (≤100 mg), urokinase (≤1 million units), or pro-urokinase (≤9 mg) with angiographic assessment of pial collateral formation.

Rates of any hemorrhage and significant hemorrhage (>25 mL) evaluated on CT 24-48 hours following symptom onset or before discharge.safety