Population
Frog semitendinosus muscle bundles (normal pHi ~7.37 and acidified pHi 5.90-6.70)
Comparison
Superfusion with Na+-free buffered solution… vs Superfusion with Na+-free buffered solution…
Design
Preclinical
Authors
Loading...
Depolarization-linked pHi shifts in acidotic muscle merit modeling in ischemia; leaves open translation to mammalian cardiac or skeletal physiology.
Depolarization of acidified frog muscle causes intracellular alkalinization driven by phosphocreatine hydrolysis, likely due to low pH inhibiting glycolysis.
Amorena et al. (1990) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: