Key result
Right ventricular systolic dysfunction (RVEF <45%) was an independent predictor of all-cause mortality in patients with HFrEF (adjusted HR 1.44; 95% CI 1.09-1.91; P=0.01).
Why the study?
While RVSD is an important determinant of heart failure outcomes and challenging to assess by 2D-echocardiography, the prognostic value of CMR-derived RV systolic function in HFrEF needed investigation.
Does CMR-derived right ventricular systolic dysfunction predict all-cause mortality in patients with HFrEF?
Population
2449 HFrEF patients with simultaneous baseline CMR and echocardiography
Comparison
RVSD (RVEF <45%) vs preserved RV function
Design
Registry-based cohort substudy
Follow-up
Median 959 days
Authors
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RV dysfunction may refine HFrEF mortality risk stratification; leaves open whether CMR integration improves outcomes in trials.
Cohort (n=2,449)
Yes
Does CMR-derived right ventricular systolic dysfunction predict all-cause mortality in patients with HFrEF?
Hazard Ratio: 1.44 (95% CI 1.09–1.91)
p-value: p=0.01
CMR-derived right ventricular systolic dysfunction is an independent predictor of all-cause mortality in patients with HFrEF, particularly in early stages of HF progression.
Al’Aref et al. (2022) conducted a cohort in Heart failure with reduced ejection fraction (HFrEF) (n=2,449). Right ventricular systolic dysfunction (RVEF <45%) vs. Absence of right ventricular systolic dysfunction was evaluated on All-cause mortality (adjusted HR 1.44, 95% CI 1.09-1.91, p=0.01). Right ventricular systolic dysfunction (RVEF <45%) was an independent predictor of all-cause mortality in patients with HFrEF (adjusted HR 1.44; 95% CI 1.09-1.91; P=0.01).