Key result
A history of hypertensive pregnancy did not alter systolic blood pressure response to isometric handgrip exercise compared to normotensive pregnancy (11.3% vs 11.5% increase).
Why the study?
Does a history of hypertensive pregnancy alter blood pressure responses to acute physical stress in postmenopausal women?
Observational (n=64)
Does a history of hypertensive pregnancy alter blood pressure responses to acute physical stress in postmenopausal women?
Absolute Event Rate: 11.3% vs 11.5%
The increased cardiovascular disease risk associated with a history of hypertensive pregnancy does not appear to be mediated by an exaggerated cardiovascular metaboreflex response to physical stress.
No difference in BP response to handgrip suggests metaboreflex does not mediate risk; leaves open alternative mechanisms in postmenopausal women.
Hypertensive pregnancy (HTNP) is a risk factor for future cardiovascular disease. Exaggerated cardiovascular responses to physical stress are also considered an independent marker of cardiovascular disease risk. However, there are limited data regarding the blood pressure (BP) responses to acute stress in women, who have a history of HTNP. Hence, the aim of the study is to compare BP responses to a physical stress in postmenopausal women with a history of HTNP to age- and parity-matched women with a history of normotensive pregnancy (NP). Beat-to-beat BP and heart rate was recorded in 64 postmenopausal women with [age = 58.5 (55.2, 62.2) yr, where values are the median, 25th percentile, and 75th percentile] and without [age = 59.4 (55.9, 62.4) yr] a history of HTNP before and during isometric handgrip (IHG) exercise (30% of maximal voluntary contraction) to fatigue. Muscle metaboreflex was measured during postexercise ischemia following IHG exercise. BP variables increased similarly in response to IHG exercise [systolic: NP = 11.5 (8.9, 17.6) %, HTNP = 11.3 (9.5, 15.9) %; diastolic NP = 11.2 (7.9, 13.3) %, HTNP = 9.5 (7.1, 14.3) %; mean blood pressure: NP = 9.8 (5.0, 13.6) %, and HTNP = 7.2 (4.4, 10.4) %] and postexercise ischemia [systolic: NP = 14.1 (10.3, 23.0) %, HTNP = 15.8 (10.6, 21.4) %; diastolic NP = 12.2 (4.8, 17.0) %, HTNP = 10.4 (5.3, 17.1) %; and mean blood pressure: NP = 11.1 (6.1, 17.9) %, HTNP = 9.4 (2.9, 14.8) %] in both groups. Although having a history of HTNP is associated with future cardiovascular disease risk, results from this study suggest that the risk may not be manifested through altered cardiovascular metaboreflex response to physical stressors.
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Ranadive et al. (2016) conducted an observational in History of hypertensive pregnancy (n=64). History of hypertensive pregnancy vs. History of normotensive pregnancy was evaluated on Systolic blood pressure increase in response to isometric handgrip exercise. A history of hypertensive pregnancy did not alter systolic blood pressure response to isometric handgrip exercise compared to normotensive pregnancy (11.3% vs 11.5% increase).
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