Key result
Young women with a family history of hypertension had greater increases in mean arterial pressure (16 vs 11 mmHg) and sympathetic nerve activity during a cold pressor test compared to those without.
Why the study?
Do young women with a family history of hypertension have exaggerated cardiovascular and sympathetic reactivity to sympathoexcitatory stimuli compared to those without?
Observational (n=29)
No
Do young women with a family history of hypertension have exaggerated cardiovascular and sympathetic reactivity to sympathoexcitatory stimuli compared to those without?
Absolute Event Rate: 16% vs 11%
p-value: p=<0.05
Young women with a family history of hypertension exhibit exaggerated blood pressure and sympathetic nerve activity responses to acute stress, which may contribute to their increased risk of developing hypertension.
May signal early risk in young women with familial hypertension; hypothesis-generating and should not yet change practice.
Young adults with a family history of hypertension (+FH) have increased risk of developing hypertension. Furthermore, the blood pressure (BP) response to sympathoexcitatory stimuli in young adults can predict the future development of hypertension. Therefore, we hypothesized young women with a +FH would have exaggerated cardiovascular and sympathetic reactivity compared with young women without a family history of hypertension (-FH). Beat-by-beat mean arterial pressure (MAP) and muscle sympathetic nerve activity (MSNA) were measured in 14 women +FH (22 ± 1 yr, 21 ± 1 kg/m(2), MAP 80 ± 2 mmHg) and 15 women -FH (22 ± 1 yr, 22 ± 1 kg/m(2), MAP 78 ± 2 mmHg) during acute sympathoexcitatory maneuvers: cold pressor test, 2 min of isometric handgrip (HG) exercise at 30% of maximal voluntary contraction, and 3 min of postexercise ischemia (PEI; isolated activation of the skeletal muscle metaboreflex). During cold pressor test, the increase in BP was greater in women +FH (ΔMAP: +FH 16 ± 2 vs. -FH 11 ± 1 mmHg, P < 0.05), which was accompanied by an exaggerated increase in MSNA (ΔMSNA: +FH 17 ± 2 vs. -FH 8 ± 2 burst/min, P < 0.05). The increase in BP was greater in +FH during the last minute of HG (ΔMAP: +FH 23 ± 3 vs. -FH 12 ± 1 mmHg, P < 0.05) and during PEI (ΔMAP: +FH 17 ± 3 vs. -FH 9 ± 2 mmHg, P < 0.05). Similarly, the increase in MSNA was greater in +FH during both HG (ΔMSNA: +FH 12 ± 2 vs. -FH 6 ± 2 burst/min, P < 0.05) and PEI (ΔMSNA: +FH 16 ± 2 vs. -FH 4 ± 2 burst/min, P < 0.05). These data demonstrate that +FH women have greater BP and sympathetic reactivity compared with -FH women.
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Greaney et al. (2015) conducted an observational in Family history of hypertension (n=29). Family history of hypertension vs. No family history of hypertension was evaluated on Change in mean arterial pressure (ΔMAP) during cold pressor test (p=<0.05). Young women with a family history of hypertension had greater increases in mean arterial pressure (16 vs 11 mmHg) and sympathetic nerve activity during a cold pressor test compared to those without.
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