October 1, 2004American Journal of Hypertension
Why the study?
Does genetic predisposition to hypertension and age influence the sympathetic nervous system response to the cold pressor test?
Population
53 subjects including 32 young subjects and 21 older subjects.
Comparison
Cold pressor test (CPT) for a 2-min period vs Resting state and comparison between groups
Design
Cross-sectional
Authors
Discussion
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Member takes
Implication
Blunted MSNA response to CPT in FH+ and hypertensive youth may reflect genetic influences; leaves open prognostic value and need for longitudinal studies.
Structured PICO
Does genetic predisposition to hypertension and age influence the sympathetic nervous system response to the cold pressor test?
P
Population
53 subjects including 32 young subjects (aged 27 +/- 2 years; 11 normotensive without family history of hypertension [FH-], 14 normotensive with strong family history [FH+], 8 hypertensive) and 21 older subjects (aged 53 +/- 2 years; 13 hypertensive, 8 normotensive).
I
Intervention
Cold pressor test (CPT) for a 2-min period
C
Comparator
Resting state and comparison between groups (normotensive vs hypertensive, FH- vs FH+, young vs older)
O
Outcome
Blood pressure (BP), heart rate (HR), and muscle sympathetic nerve activity (MSNA) at rest and during a 2-min period of a CPTsurrogate
Hypertensive patients and those with a family history of hypertension exhibit subnormal sympathetic responses to the cold pressor test, highlighting the role of genetic factors in sympathetic reactivity.
Cite This Study
Markus P. Schlaich (2004) studied this question.