Key result
A family history of hypertension in young adults was associated with higher clinic systolic blood pressure (SMD 3.13 mmHg; 95% CI 1.75-4.51; P<0.001) and negatively impacted heart rate variability.
Why the study?
This study evaluated the impact of a family history of hypertension on blood pressure and heart rate variability in young adults.
Does a family history of hypertension impact blood pressure and heart rate variability in young adults?
Meta-Analysis (n=2,025)
Does a family history of hypertension impact blood pressure and heart rate variability in young adults?
Effect estimate: SMD 3.13 mmHg (95% CI 1.75-4.51)
p-value: p=<0.001
A family history of hypertension is associated with higher blood pressure and reduced heart rate variability in healthy young adults, indicating early autonomic and hemodynamic alterations.
May support earlier BP screening in young adults with familial risk; extends meta-analytic data to autonomic measures.
PURPOUSE: This meta-analysis evaluates the impact of family history of hypertension (FHH + ) on blood pressure (BP) and heart rate variability (HRV) in young adults. METHODS: Observational studies that evaluated adults (aged between 18 and 40 years) of both sexes, are without cardiometabolic disease diagnosis, are published in English, and are reporting on the influence of FHH + (father, mother, or both) on BP and HRV were included. In June 2021, we made a search of the electronic database MEDLINE (accessed by PubMed). Random-effects models were used, and data are reported as standardized mean difference and 95% confidence limits. RESULTS: Thirty-eight studies with a total of 2025 individuals were included. Clinic systolic [3.13 mmHg (1.75-4.51)] and diastolic [2.85 mmHg (1.65-4.04)] BPs were higher ( P < 0.001) in individuals with an FHH + . Only 24-h systolic BP was higher [1.76 mmHg (0.05-3.47); P = 0.04] in individuals with an FHH + . As for HRV indices in time-domain, RMSSD: -7.00 ms (-10.75 to -3.26), SDNN: -13.93 ms (-23.56 to -4.30), and HF [-6.82 n. u. (-9.76 to -3.89)] were lower ( P < 0.05), and LF [4.78 ms (2.52-7.03)] and LF/HF ratio [0.32 (0.14-0.50)] were higher ( P < 0.001) in individuals with an FHH + . CONCLUSION: FHH + negatively impacts BP and HRV in young adults.
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Queiroz et al. (2022) conducted a meta-analysis in Family history of hypertension (n=2,025). Family history of hypertension (FHH+) vs. No family history of hypertension was evaluated on Clinic systolic blood pressure (SMD 3.13 mmHg, 95% CI 1.75-4.51, p=<0.001). A family history of hypertension in young adults was associated with higher clinic systolic blood pressure (SMD 3.13 mmHg; 95% CI 1.75-4.51; P<0.001) and negatively impacted heart rate variability.
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