Key result
Evaluating 21 different published parameter sets in a finite element model of the human ventricle revealed that calculated systolic stresses were largely insensitive to the chosen parameter set.
Why the study?
Estimating cardiac stress and strain with computational models requires knowing tissue material properties and the unloaded state, both of which are difficult to determine.
Population
Finite element model of the human ventricle
Comparison
21 different published parameter sets for five passive material model parameters
Design
Computational simulation sensitivity study
Authors
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Systolic stress estimates in ventricular models may tolerate parameter variability; leaves open precise material properties for strain analyses.
Determining the correct material and unloaded configuration is highly important for understanding strain-driven processes, but less critical for calculating stress estimates in cardiac mechanical models.
Kallhovd et al. (2019) studied Cardiac mechanics. Passive material parameter sets was evaluated on Sensitivity of stress and strain calculations. Evaluating 21 different published parameter sets in a finite element model of the human ventricle revealed that calculated systolic stresses were largely insensitive to the chosen parameter set.
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