Key result
Daily olive oil and flaxseed improves FMD and reduces inflammation and total cholesterol in CHD.
Why the study?
A healthy lifestyle improves cardiovascular risk factors, but the specific effect of olive oil and flaxseed consumption on endothelial function, inflammatory factors, and lipid profile in CHD patients needed assessment.
Does consumption of olive oil and flaxseed improve endothelial function, plasma inflammatory factors, and lipid profile in patients with coronary heart disease?
RCT (n=50)
Open-label
randomized
Does consumption of olive oil and flaxseed improve endothelial function, plasma inflammatory factors, and lipid profile in patients with coronary heart disease?
Inclusion of olive oil and flaxseed in the diet of CHD patients improves endothelial function and reduces inflammatory markers, suggesting a role in secondary prevention.
Answers are grounded in this paper and cite their sources.
Supports incorporating olive oil and flaxseed into CHD diets; reinforces RCT evidence for dietary approaches in secondary prevention.
OBJECTIVES: A healthy lifestyle, including a healthy diet has been associated with an improvement in cardiovascular risk factors. The aim of the present study was to assess the effect of olive oil and flaxseed consumption as part of a healthy diet on endothelial function, plasma inflammatory factors, and lipid profile in patients with coronary heart disease (CHD). METHOD: This randomized nonblinded trial was performed on CHD patients. In the control group, participants received general heart-healthy dietary recommendations while in the intervention group, in addition to these recommendations, the participants consumed 25 ml of olive oil and 30 g of flaxseeds daily for 3 months. At baseline and after 3 months, changes in brachial flow-mediated dilation (FMD), plasma asymmetric dimethyl arginine, interleukin-6 (IL-6), IL-10, high-sensitivity C-reactive protein (hs-CRP), tumor necrosis factor-α (TNF-α), monocyte chemoattractant protein-1 (MCP-1), and lipids and lipoproteins were measured. RESULTS: A total of 50 patients finished the trial ( n = 24 in the intervention and n = 26 in the control groups). Compared to the control group, consumption of flaxseed and olive oil significantly improved brachial artery FMD%, and reduced plasma IL-6, TNF-α, MCP-1, total cholesterol, and tended to reduce hs-CRP, and non-HDL-cholesterol but the concentration of other study indices were not different between the two groups. CONCLUSION: Inclusion of olive oil and flaxseed in the diet of CHD patients may contribute to secondary prevention by improving endothelial function and plasma inflammatory factors.
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Khandouzi et al. (2023) conducted an RCT in coronary heart disease (CHD) (n=50). Olive oil and flaxseed vs. General heart-healthy dietary recommendations was evaluated on brachial flow-mediated dilation (FMD), plasma inflammatory factors, and lipid profile. Daily consumption of 25 ml olive oil and 30 g flaxseed significantly improved brachial artery FMD% and reduced plasma IL-6, TNF-α, MCP-1, and total cholesterol in CHD patients.
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