Key result
Canola oil lowers LDL-cholesterol by ~0.3 mmol/L and improves endothelial function in PAD.
Why the study?
The effects of supplementation with plant-derived omega-3 and omega-6 PUFAs on patients with atherosclerosis and peripheral arterial occlusive disease were not well studied.
Does canola oil supplementation improve endothelial function and reduce cholesterol in patients with peripheral arterial occlusive disease?
RCT (n=40)
Double-blind
Randomized in blocks of four
No
Does canola oil supplementation improve endothelial function and reduce cholesterol in patients with peripheral arterial occlusive disease?
Dietary supplementation with canola oil for 8 weeks improved endothelial function and reduced LDL-cholesterol in patients with peripheral arterial disease.
Canola oil may improve endothelial function and lower LDL in PAD; leaves open whether benefits extend to clinical outcomes in larger trials.
Background: Dietary supplementation with omega-3 PUFAs has been shown to reduce cardiovascular morbidity and mortality.This pilot study investigated the effects of supplementation with plant-derived omega-3 and omega-6 PUFAs in patients with atherosclerosis.Methods: Forty patients with PAD supplemented their usual diet with 2 tablespoons/day of canola oil (n Z 20) or sunflower oil (n Z 20), containing 2.24 g of a-linolenic acid or 16.24 g of linoleic acid, respectively, for 8 weeks.Laser Doppler flux (LDF), was assessed at rest and during reactive hyperaemia.Other measurements included parameters of heart rate variability (HRV), markers of plasmatic coagulation, fibrinolysis, platelet activation, inflammation, and lipid and homocysteine levels.Results: Despite randomization, baseline values for LDF and HRV differed between the two groups.LDL-cholesterol decreased (from 2.74 Æ 0.73 to 2.42 Æ 0.65 mmol/L, p Z 0.007) with canola oil but not with sunflower oil.The difference in the percent increase of LDF after ischemic challenge increased with canola oil from a median (25th; 75th percentiles) of 75.2% (48.6; 161.2) to 151.7% (117.8;260.0) (p Z 0.008) and with sunflower oil from 157.9% (125.4;229.8) to 178.6% (127.3;356.3) (p Z 0.03), whereas a control group did show no change.HRV and other markers did not change.
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Stricker et al. (2008) conducted an RCT in Peripheral arterial occlusive disease (n=40). Canola oil vs. Sunflower oil (2 tablespoons/day) was evaluated on LDL-cholesterol (MD 0.31 mmol/L reduction, 95% CI 0.1-0.53, p=0.007). Canola oil supplementation for 8 weeks significantly reduced LDL-cholesterol by 0.31 mmol/L and improved endothelial function in patients with peripheral arterial occlusive disease.
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