Key result
Canola oil consumption significantly reduced plasma Lp-PLA2 mass compared to olive oil, whereas olive oil was more effective in reducing interleukin-6 levels in patients referred for coronary angiography.
Why the study?
While potential cardioprotective benefits of olive oil and canola oil consumption have been shown in some studies, their comparative effects on plasma lipids, inflammatory cytokines, and Lp-PLA2 mass and activity in patients undergoing coronary angiography remained to be compared.
Does canola oil compared to olive oil improve plasma lipids, Lp-PLA2, and inflammatory cytokines in patients referred for coronary angiography?
RCT (n=48)
Open-label
Simple randomization using computerized random numbers
No
Does canola oil compared to olive oil improve plasma lipids, Lp-PLA2, and inflammatory cytokines in patients referred for coronary angiography?
Differential biomarker effects warrant no oil preference change; leaves open outcome trials in CAD patients.
Background The potential cardioprotective benefits of olive oil (OO) and canola oil (CO) consumption have been shown in some studies. The present study compared the effects of CO and OO on plasma lipids, some inflammatory cytokines, and lipoprotein-associated phospholipase A 2 (Lp-PLA 2 ) mass and activity in patients undergoing coronary angiography. Methods The current randomized, controlled, parallel-arm, clinical trial involved 48 patients (44 men and 4 women, aged 57.63 ± 6.34 years) with at least one classic cardiovascular risk factor (hypertension, dyslipidemia, or diabetes) who referred for coronary angiography. Patients were randomly divided into two groups and received 25 mL/day refined olive oil ( n = 24) or canola oil ( n = 24) for 6 weeks. Plasma lipids, some selected inflammatory markers, and Lp-PLA 2 levels were measured at baseline and after the intervention. Results CO consumption produced a significant reduction in plasma Lp-PLA 2 mass (− 0.97 ± 1.84 vs. 0.34 ± 1.57 ng/mL, p = 0.008 for CO and OO, respectively), whereas the mean changes in interleukine-6 concentration were significantly lower after OO consumption compared with CO (− 9.46 ± 9.46 vs. -0.90 ± 6.80 pg/mL, p = 0.008 for OO and CO, respectively). After 6 weeks of intervention, no significant changes were observed in plasma Lp-PLA 2 activity, complement C3, C4, or lipid profiles in the two intervention groups. Conclusions Comparing the two vegetable oils in subjects with cardiovascular risk factors showed that the consumption of olive oil is more effective in reducing the level of inflammatory cytokine interleukine-6, whereas canola oil was more effective in lowering Lp-PLA 2 levels; however, this finding should be interpreted with caution, because Lp-PLA 2 activity did not change significantly. Trial registration IRCT20160702028742N5 at www.irct.ir (04/19/2019).
No takes yet. Share an insight, caveat, or question.
Khandouzi et al. (2020) conducted an RCT in Cardiovascular risk factors in patients referred for coronary angiography (n=48). Canola oil vs. Olive oil (25 mL/day) was evaluated on Change in plasma Lp-PLA2 mass (ng/mL) (p=0.008). Canola oil consumption significantly reduced plasma Lp-PLA2 mass compared to olive oil, whereas olive oil was more effective in reducing interleukin-6 levels in patients referred for coronary angiography.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: