Key result
Among 50 patients with rheumatic mitral valve disease, left atrial functions were significantly reduced, particularly in the 14 patients with combined mitral stenosis and regurgitation.
Why the study?
Left atrial function modulates left ventricular performance, and 2D speckle tracking echocardiography provides a feasible approach to detect subclinical dysfunction in rheumatic mitral valve disease.
Observational (n=50)
No
Left atrial reservoir, conduit, and contractile functions, as well as global longitudinal strain, are significantly impaired in patients with rheumatic mitral valve disease, particularly those with combined lesions.
LA impairment may signal greater severity in combined lesions; leaves open its prognostic role in rheumatic mitral valve disease.
Background: The assessment of Left Atrial (LA) function is used in various cardiovascular diseases. LA plays a com-plementary role in cardiac performance by modulating Left Ventricular (LV) function. Transthoracic two-dimensional (2D) phasic volumes and Doppler echocardiography can measure LA function non-invasively. However, evaluation of LA deformation derived from 2D Speckle Tracking Echocar-diography (STE) is a new feasible and promising approach for assessment of LA mechanics. These parameters are able to detect subclinical LA dysfunction in different pathological condition.Aim of Study: To assess left atrial function by conventional echo Doppler study and tissue Doppler based strain imaging as well as global longitudinal strain in patients with rheumatic mitral valve disease.Patients and Methods: A total of 50 rheumatic mitral valve disease patients appearing consecutively for echocardi-ogram (ECHO) test at the Cardiology Department in a tertiary care hospital were recruited into the study as per the pre-set inclusion and exclusion criteria. The data were pooled using Microsoft Excel and analysed using SPSS software by appli-cation of appropriate statistical tests.Results: Of the 50 subjects, 22 had Mitral Stenosis (MS), 14 had Mitral Regurgitation (MR), and 14 of them were found to have both MS and MR. The major presenting symptom as observed in 23 patients was dyspnea. LA functions were significantly reduced in double mitral lesion group which was observed in LA indices such as LA emptying fraction, LA passive emptying fraction, atrial fraction, and LA expansion index among groups.Conclusion: LA reservoir, conduit and contractile function were significantly affected in rheumatic mitral valve disease due to increased hemodynamic load. Global longitudinal strain was significantly reduced in patients with MS and MR.
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EL-SHAFAI et al. (2019) conducted an observational in Rheumatic mitral valve disease (n=50). Rheumatic mitral valve disease (double vs single lesions) was evaluated on Left atrial function (LA emptying fraction, LA passive emptying fraction, atrial fraction, LA expansion index, and global longitudinal strain). Among 50 patients with rheumatic mitral valve disease, left atrial functions were significantly reduced, particularly in the 14 patients with combined mitral stenosis and regurgitation.
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