October 1, 1995British Journal of PharmacologyOpen Access

Interaction of the antiarrhythmic agents SR 33589 and amiodarone with the β‐adrenoceptor and adenylate cyclase in rat heart

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Population

Rat heart (in vitro and in vivo models)

Design

Preclinical

Follow-up

14 days (for chronic treatment)

Authors

PCPierre ChatelainUniversité Claude Bernard Lyon 1 LML. MeysmansSanofi (Belgium)JMJ.R. MattéazziSanofi (Belgium)

Discussion

Member takes

Implication

Hypothesis-generating for SR 33589 beta-blockade; leaves open clinical relevance beyond amiodarone's established use.

Structured PICO

Population

Rat heart (in vitro and in vivo models)

Intervention

SR 33589 and amiodarone (in vitro application and chronic oral treatment at 50, 100, 150 mg/kg per day for 14 days)

Outcome

Cardiac beta-adrenoceptor binding ([125I]-(-)-CYP) and adenylate cyclase activitysurrogate

SR 33589 and amiodarone act as non-competitive beta-adrenoceptor antagonists and cause receptor down-regulation after chronic use, likely by interacting near intracellular coupling loops.

Cite This Study

Chatelain et al. (1995) studied this question.

synapsesocial.com/papers/6a2115aa38e3bbbbff02b554 https://doi.org/10.1111/j.1476-5381.1995.tb16397.x

View Full Paper

Ask AI

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Interaction of the antiarrhythmic agents SR 33589 and amiodarone with the β‐adrenoceptor and adenylate cyclase in rat heart

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Interaction of the antiarrhythmic agents SR 33589 and amiodarone with the β‐adrenoceptor and adenylate cyclase in rat heart

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider