Correction: Li et al. The Anthraquinone Derivative C2 Enhances Oxaliplatin-Induced Cell Death and Triggers Autophagy via the PI3K/AKT/mTOR Pathway. Int. J. Mol. Sci. 2024, 25, 6468

Figures

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  Figure 4. C2 enhanced L-OHP-induced apoptosis and autophagy. (A,B) Flow cytometry was used to analyze the effect of C2 on L-OHP-induced apoptosis. (C,D) Expression of Bcl-2 and cleaved caspase 3 was examined by Western blotting analysis. (E) MDC staining was performed to analyzed the C2-enhanced L-OHP-induced autophagy by the laser confocal microscope (60×). All data represent the mean ± standard deviation of three independent experiments. * p < 0.05, ** p < 0.01, *** p < 0.001.

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  Figure 5. C2 enhances L-OHP-induced autophagy by modulating the PI3K/AKT/mTOR pathway. (A,B) Expression of PI3K, AKT, mTOR, p-AKT, and p-mTOR was examined by Western blotting analysis. (C,D) Expression of Beclin 1 and LC3B was examined by Western blotting analysis. All data represent the mean ± standard deviation of three independent experiments. * p < 0.05, ** p < 0.01, *** p < 0.001.

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  Figure 6. The combination of C2 and L-OHP induced protective autophagy. (A,B) Flow cytometry was used to analyze the effect of 3-MA (100 μΜ) on C2 + L-OHP-induced apoptosis. (C) Cell viability of 3-MA combined with C2 + L-OHP treatment by MTT. (D,E) Expression of Bcl-2 and cleaved caspase3 was examined by Western blotting analysis after 3-MA combined with C2 + L-OHP treatment. All data represent the mean ± standard deviation of three independent experiments. * p < 0.05, ** p < 0.01.