Carotid Arterial Stiffness and Its Relationship to Exercise Intolerance in Older Patients With Heart Failure and Preserved Ejection Fraction
Key result
Older patients with HFpEF had reduced carotid arterial distensibility compared with older healthy subjects (0.97 vs 1.33 ×10⁻³ mm Hg⁻¹; P=0.008), which correlated with exercise intolerance.
Population
131 subjects total: 69 patients ≥60 years of age with heart failure with preserved ejection fraction, and 62…
Design
Cross-sectional
Authors
Discussion
Loading...
Member takes
Implication
Hypothesis-generating for carotid stiffness in HFpEF; prospective trials needed before clinical consideration.
Study Design
Type
Observational (n=131)
Structured PICO
P
Population
131 participants, including 69 patients ≥60 years with HFpEF and 62 healthy volunteers, evaluated for carotid arterial stiffness and exercise intolerance.
C
Comparator
Older healthy subjects (≥60 years) and young healthy subjects (≤30 years)
O
Outcome
Carotid arterial stiffness (assessed by distensibility and Young's elastic modulus using high-resolution ultrasound) and peak exercise oxygen consumption (measured using expired gas analysis)surrogate
Main Result
Absolute Event Rate: 0.97% vs 1.33%
p-value: p=0.008
Carotid arterial stiffness is increased in older patients with HFpEF beyond normal aging and correlates with severe exercise intolerance, suggesting it as a potential therapeutic target.
Cite This Study
Kitzman et al. (2012) conducted an observational in Heart failure with preserved ejection fraction (HFpEF) (n=131). Heart failure with preserved ejection fraction (HFpEF) vs. Older healthy subjects was evaluated on Carotid arterial distensibility (×10⁻³ mm Hg⁻¹) (p=0.008). Older patients with HFpEF had reduced carotid arterial distensibility compared with older healthy subjects (0.97 vs 1.33 ×10⁻³ mm Hg⁻¹; P=0.008), which correlated with exercise intolerance.