Key result
A novel minimally invasive coil embolization approach targeting a specific area of myocardium yielded a consistent scar encompassing ~30% of the left ventricular free wall in young and aged rabbits.
A novel minimally invasive coil embolization method produces a consistent ~30% left ventricular free wall infarct in both young and aged rabbits, providing a standardized large animal model for studying myocardial infarction across age cohorts.
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Enables standardized age-comparative MI research in rabbits; leaves open any clinical translation pending prospective validation.
The incidence of both myocardial infarction (MI) and sudden cardiac death increases with age. Here, we describe the development of a minimally invasive large animal model of MI that can be applied to young or aged animals. We demonstrate that rabbit coronary anatomy is highly variable, more so than described in previous literature. In this work, we categorize the coronary pattern of 37 young rabbits and 64 aged rabbits. Aged rabbits had a higher degree of branching from the left main coronary artery. Standardizing the model across age cohorts required a new approach, targeting an area of myocardium rather than a specific vessel. Here, we present a method for achieving a reproducible infarct size, one that yielded a consistent scar encompassing ~30% of the apical left ventricular free wall. The model’s consistency allowed for more valid comparisons of MI sequelae between age cohorts. NEW & NOTEWORTHY This study describes the coronary angiographic imaging of young and aged rabbits. We developed and improved a novel minimally invasive approach for coil embolization that targets a specific area of myocardium and yielded a consistent scar encompassing ~30% of the left ventricular free wall of young and aged rabbit hearts.
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Morrissey et al. (2017) studied Myocardial infarction (animal model) (n=101). Minimally invasive coil embolization targeting a specific area of myocardium was evaluated on Reproducible infarct size (scar encompassing ~30% of the apical left ventricular free wall). A novel minimally invasive coil embolization approach targeting a specific area of myocardium yielded a consistent scar encompassing ~30% of the left ventricular free wall in young and aged rabbits.
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